This is a hybrid event. A Zoom link will be sent out to those registered through Eventbrite.
About the Event
The seminar will describe two novel classes of anticancer compounds derived from the nonsteroidal anti-inflammatory drug, sulindac, designed to lack cyclooxygenase inhibitory activity. A lead compound from the first class, ADT-007, shows ultra-high potency and selectivity to inhibit the growth of cancer cells harboring RAS mutations and acts as a pan-RAS inhibitor with potential advantages over mutant specific KRAS inhibitors. The other class inhibits phosphodiesterase 10A and activates cGMP/PKG signaling to suppress Wnt/β-catenin transcriptional activity.
About the Speaker
Gary A. Piazza received a Ph.D. in pharmacology from The University of Alabama at Birmingham in 1986, completed a postdoctoral fellowship at the Fox Chase Cancer Center, and was a Research Assistant Professor at Brown University. Dr. Piazza worked in the pharmaceutical industry as a Staff Scientist with the Proctor and Gamble Company from 1989-1994 and as Senior Director of Biology with Cell Pathways Inc. from 1994-2001. From 2001-2003, Dr. Piazza served as the Director of Pharmacology at the University of Texas Institute for Drug Development in San Antonio. From 2003-2011, Dr. Piazza was a principal investigator at Southern Research in Birmingham on numerous grants and contracts and a program director for a NIH-funded molecular libraries screening center. From 2011-2021, Dr. Piazza was appointed Professor of Oncologic Sciences and Pharmacology and Chief of the Drug Discovery Research Center.
Dr. Piazza joined Auburn University in 2021 as Professor and Head of the Department of Drug Discovery and Development and Director of the Cancer Research Center in the Harrison College of Pharmacy. Dr. Piazza’s research interests are in the discovery and development of experimental anticancer drugs that target RAS and Wnt/β-catenin signaling. His research has been funded continuously by the NIH since 2004. Dr. Piazza has over 140 publications and is an inventor on numerous patents. He is a Fellow of the National Academy of Inventors.
Please direct any questions to: Nadine Peterson, DDI Coordinator at ddicoordinator@gmail.com
Zoom link will be sent from Eventbrite to attendees one day before the event.
